The results of our process development studies to synthesize the methanol solvate of (S)-omeprazole potassium salt (1) through the enantioselective oxidation of pyrmetazole (2) using (1R)-(−)-10-camphorsulfonyloxaziridine (3) are reported. Optical purity enhancement was achieved by means of a reslurry from methanol, the rationale and development details of which are also described.
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Authors: Christine Delsarte, Romuald Santraine, Baptiste Fours*, and Laurent Petit* –
Minakem Recherche, 145 Chemin des Lilas, 59310 Beuvry la Forêt, France
Source: Org. Process Res. Dev., 2018, 22 (3), pp 321–327
Publication Date (Web): March 2, 2018
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