An improved synthesis of 1-methylcyclopropanol using the Kulinkovich reaction


An improved process for the preparation of 1-methylcyclopropanol using the Kulinkovich reaction is described. The use of titanium tetramethoxide as catalyst resulted in minimal side product formation. The reaction, isolation and purification procedures were optimized so they can be easily implemented in multi-purpose equipment.

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Source: Bioorganic & Medicinal Chemistry, Volume 26, Issue 4, 15 February 2018, Pages 984-988
Authors: Christine Delsarte, Guillaume Etuin, Laurent Petit
Minakem Recherche, 145 chemin des Lilas, 59310 Beuvry-La-Forêt, France

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