{"id":28915,"date":"2025-02-11T17:11:28","date_gmt":"2025-02-11T16:11:28","guid":{"rendered":"https:\/\/minakem.com\/solid-state\/"},"modified":"2025-05-12T16:53:48","modified_gmt":"2025-05-12T14:53:48","slug":"etat-solide","status":"publish","type":"page","link":"https:\/\/minakem.com\/fr\/etat-solide\/","title":{"rendered":"\u00c9tat solide"},"content":{"rendered":"
<\/div>

\u00c9tat solide<\/h1>\n<\/div><\/div>
<\/div>

Comprendre l’espace de conception Solid State \/ des particules est essentiel au d\u00e9veloppement r\u00e9ussi de nombreux Principes Actifs Pharmaceutiques (API). Notre \u00e9quipe d\u00e9di\u00e9e \u00e0 l’\u00e9tat solide, int\u00e9gr\u00e9e \u00e0 notre d\u00e9partement R&D, offre un support complet pour le d\u00e9veloppement des projets de nos clients. Cette approche garantit que l’expertise en mati\u00e8re d’\u00e9tat solide est une partie fondamentale de chaque \u00e9tape du d\u00e9veloppement de proc\u00e9d\u00e9, offrant ainsi des r\u00e9sultats de grande valeur.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

\"\"<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>
<\/div>
<\/div>

Notre \u00e9tat solide<\/h1>\n<\/div><\/div>
<\/div>

Nos \u00e9tudes sur l’\u00e9tat solide vont au-del\u00e0 de l’exploration du paysage polymorphique d’un API ou HPAPI et de son impact sur la biodisponibilit\u00e9.<\/p>\n

Elles constituent un \u00e9l\u00e9ment essentiel du d\u00e9veloppement de proc\u00e9d\u00e9, combinant rigueur scientifique et approche ax\u00e9e sur la fabrication, notamment pour :<\/p>\n<\/div><\/div>

<\/div>

S\u00e9lectionner le candidat
\ncristallin optimal<\/span><\/h3>\n

Nous \u00e9valuons soigneusement la forme et la morphologie cristalline pour garantir le candidat le plus appropri\u00e9 pour la production et la performance.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

D\u00e9velopper des proc\u00e9d\u00e9s de cristallisation
\n\u00e0 l’\u00e9chelle industrielle<\/span><\/h3>\n

Nos proc\u00e9d\u00e9s robustes sont con\u00e7us pour une transposition d’\u00e9chelle fluide du laboratoire \u00e0 la production, assurant des propri\u00e9t\u00e9s de filtration ad\u00e9quates et r\u00e9pondant aux attributs de qualit\u00e9 requis du produit final.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>

<\/div>

D\u00e9finir des param\u00e8tres d’ensemencement robustes<\/h3>\n

Gr\u00e2ce \u00e0 la d\u00e9termination de la largeur de la zone m\u00e9tastable, nous \u00e9tablissons des points d’ensemencement pr\u00e9cis pour une cristallisation contr\u00f4l\u00e9e.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

Mener des \u00e9tudes<\/span>
\nde criblage compl\u00e8tes<\/span><\/h3>\n

Nous r\u00e9alisons des criblages approfondis des polymorphes, des sels et des co cristaux, incluant la caract\u00e9risation et les \u00e9valuations de stabilit\u00e9 relative.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>

<\/div>

Optimiser la r\u00e9solution chirale<\/span><\/h3>\n

Notre \u00e9quipe am\u00e9liore la processabilit\u00e9 gr\u00e2ce \u00e0 des approches avanc\u00e9es pour la formation de sels diast\u00e9r\u00e9oisom\u00e8res et l’entra\u00eenement.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

Concevoir des proc\u00e9d\u00e9s \u00e0 l’\u00e9chelle industrielle<\/h3>\n

Les \u00e9tudes de solubilit\u00e9 et les investigations de diagrammes de phases nous permettent de d\u00e9velopper des proc\u00e9d\u00e9s pr\u00eats pour une mise en \u0153uvre \u00e0 l’\u00e9chelle industrielle.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>

<\/div>

Am\u00e9liorer la filtration et le s\u00e9chage<\/h3>\n

En \u00e9valuant la r\u00e9sistance sp\u00e9cifique du g\u00e2teau et la compressibilit\u00e9, nous optimisons les performances de filtration et de s\u00e9chage.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

Affiner la taille des particules<\/span><\/h3>\n

Nous exploitons des technologies avanc\u00e9es de broyage sec et humide ainsi que de micronisation pour un contr\u00f4le pr\u00e9cis de la taille des particules.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>

<\/div>

Contr\u00f4ler la distribution granulom\u00e9trique<\/span><\/h3>\n

Nous g\u00e9rons m\u00e9ticuleusement la taille des particules pour respecter les sp\u00e9cifications strictes de nos clients.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

Prot\u00e9ger la propri\u00e9t\u00e9 intellectuelle (PI)<\/h3>\n

Notre expertise soutient le d\u00e9veloppement de la PI pour prot\u00e9ger les innovations.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>

<\/div>\"\"<\/div><\/div><\/div><\/div><\/div>

Notre \u00e9quipement de pointe<\/h2>\n<\/div><\/div>
<\/div>

Pour la caract\u00e9risation de l’\u00e9tat solide, permettant une analyse approfondie des propri\u00e9t\u00e9s physiques et thermodynamiques de vos compos\u00e9s.<\/p>\n

Gr\u00e2ce \u00e0 des technologies de pointe telles que la DRX (Diffraction des rayons X sur poudres), l’ATG-DSC (Analyse Thermogravim\u00e9trique – Calorim\u00e9trie Diff\u00e9rentielle \u00e0 Balayage), la microscopie et la diffraction laser pour l’analyse de la taille des particules, nous assurons une \u00e9valuation approfondie.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>

<\/div>

Une \u00e9quipe int\u00e9gr\u00e9e \u00e0 la R&D<\/h2>\n<\/div><\/div><\/div><\/div><\/div>

En int\u00e9grant notre \u00e9quipe d\u00e9di\u00e9e \u00e0 l’\u00e9tat solide d\u00e8s le d\u00e9but de votre projet, Minakem s’assure que l’expertise en cristallisation est int\u00e9gr\u00e9e \u00e0 votre proc\u00e9d\u00e9 de fabrication.<\/p>\n

Cette approche collaborative rationalise l’optimisation des proc\u00e9d\u00e9s et le d\u00e9pannage, offrant des solutions fiables et de haute qualit\u00e9 adapt\u00e9es aux exigences de nos clients.<\/p>\n

\u00catre partenaire de Minakem signifie b\u00e9n\u00e9ficier d’une approche innovante et int\u00e9gr\u00e9e du d\u00e9veloppement d’API et d’HPAPI, o\u00f9 l’excellence en cristallisation g\u00e9n\u00e8re des r\u00e9sultats remarquables.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"\u00c9tat solide Comprendre l’espace de conception Solid State \/ des particules est essentiel au d\u00e9veloppement r\u00e9ussi de nombreux Principes Actifs Pharmaceutiques (API). Notre \u00e9quipe d\u00e9di\u00e9e \u00e0 l’\u00e9tat solide, int\u00e9gr\u00e9e \u00e0 notre d\u00e9partement R&D, offre un support complet pour le d\u00e9veloppement des projets de nos clients. Cette approche garantit que l’expertise en mati\u00e8re d’\u00e9tat solide est...","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-28915","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nSolid State Chemistry for Pharmaceutical Manufacturing | Minakem<\/title>\n<meta name=\"description\" content=\"Minakem specializes in solid-state chemistry, offering expertise in crystallization and polymorph studies for pharmaceutical development.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minakem.com\/fr\/etat-solide\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c9tat solide\" \/>\n<meta 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